Background/Aims: It has been demonstrated that KRAS mutations represent about 90% of cancer-associated mutations, and that KRAS mutations play an essential role in neoplastic transformation.Cancer-associated RAS mutations occur frequently in acute myeloid leukemia (AML), suggesting a functional role for Ras in leukemogenesis.Methods: We successfull
Kathleen Reid,1 Elizabeth A Ayello,2 Afsaneh Alavi,3 1Department of Nursing Practice and Education, Bridgepoint Active Healthcare, Toronto, Canada; 2School of Nursing, Excelsior College, Albany, NY, USA; 3Department of Medicine, University of Toronto, Toronto, Canada Abstract: The management of pressure ulcers is challenging for health care pr
ObjectiveThe role of resection in progressive glioblastoma (GBM) to prolong survival is still controversial.The aim of this study was to determine 1) the predictors of post-progression survival (PPS) in progressive GBM and 2) which subgroups of patients would benefit from recurrent resection.MethodsWe have conducted a retrospective bicentric cohort
Michael J BurkeDepartment of Pediatrics, Division of Hematology/Oncology/Bone Marrow Transplantation, Medical College of Wisconsin, Milwaukee, WI, USAAbstract: Using targeted therapy for treatment of cancer has become the paradigm to which clinical trials aspire.Imatinib, the BCR-ABL1 tyrosine kinase inhibitor (TKI), was the first of its kind to sp
The aricle consists ofive argumentaive sections.The first deals with the textual evidence with regard to the expressions "disciples", "the Twelve" and "apostles".In the second section it is argued that Jesus did not create the idea of "the Twelve".Firstly, the argument focuses on a discussion of the differences and similarities in the lists of twel